This article reminds me of the free issue of Whole Earth Journal I received about ten years ago. The theme of the article was "Is the Body Obsolete?" The question was posed to a number of different people in a number of different occupations.
The basic premise of the question had a lot to do with the fears and possibilities deriving from some of the very same research Andrea describes in the article (esp. nanotechnology). The basic answer to the question, by the majority of respondents, was "Bunk!"
My (highly uneducated) guess on the subject is that people will choose to use these technologies if they are available, affordable, and appropriate (much like the World Wide Web right now)...unless government or some other all-powerful entity of an unknown future makes that choice for us.

Mr. Joy is a classic example of the scienist screaming "Wolf!" in order to justify his creation. In the U.S. there are people livingÑby circumstance and not by choiceÑwithout electricity (outside of CA), running water or indoor plumbing (I don't refer to the homeless). How are these people going to be effected by the technology Mr. Joy describes? Will they be assimilated? Technology is an issue of economics, not evolution. Those who can afford it, have it. Less Hollywood science fantasy and more science reality.